We classified tumor recurrence into early or late with 12 months as the cut-off point,[ 13, 14] and the number of recurrent nodules into single or multiple recurrence.
And we also are the first ones to find elevated PLUNC expression in multiple recurrence sinonasal IPs.
The aim of this prospective study was to identify a new biomarker for predicting multiple recurrence of EGC after ESD.
Meanwhile, grade of gastric atrophy was also identified as a significant marker of multiple recurrence (HR, 4.95; 95% CI, 1.30 18.8).
The stains revealed significantly elevated levels of PLUNC, but decreased levels of Ki-67, p53, p21, and p27 in patients with multiple recurrence of IPs (Table 1).
A few studies have classified multiple recurrence as synchronous (<12 months) and metachronous (>12 months; Nasu et al, 2005; Nakajima et al, 2006).
Multiple recurrence was observed in 85.7% of Gp1, which was also significantly higher than Gp3 and Gp4 (P = 0.039 and 0.036, respectively).
In epidemiological studies where some participants are related either genetically or are from the same family, share some unmeasured covariates, or have multiple recurrence events, their survival times are not independent due to within -subject dependency (15).
