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The problem with prediction of subcellular localization at the domain level is that the same domain can exist on multiple proteins which can be localized to different subcellular locations.
Previous studies in other cell types and tissues have identified multiple proteins, which may associate with MeCP2 leading to modulation of gene expression.
This has been reported to be the binding site of multiple proteins, which dynamically interact, and participate in the regulation of physiological events (for review, see Giepmans).
Lastly, we link scaffolds into super-scaffolds by examining contigs with multiple proteins which, in turn, are assigned to multiple contigs.
First, we looked for alignment of the initial Methionine (Met) amino acid to a downstream Met in multiple proteins, which may point to the less common initial Met being an incorrect translation start position.
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While most studies have utilized single oligos either administered alone, or more recently in combination therapy with other drugs, some investigators have administered more than one oligo in a combined administration or have designed oligos which target multiple proteins (those which share mRNA sequence homology).
Both types of signaling enzymes are multiple domain proteins which often contain, in addition to their core catalytic function, multiple independently folding domains or motifs that mediate connectivity by interacting with other signaling elements [ 27].
Additionally, it is an observed fact that a single bacterium may possess multiple putative proteins which code for GGD /E EF or EAL or both.
This activates multiple downstream proteins, which play functional roles in cell survival, proliferation vascular permeability and stabilization of new blood vessels [ 4- 6].
Similarly, transcription termination involves the binding of multiple accessory proteins which may affect the pattern of mutations and repair at the 3'-end.
A single primary transcript is responsible for the production of multiple retrotransposon proteins, which are essential for the autonomous replication of the corresponding element, and is subjected to ribosomal frameshifting to maintain a proper ratio between the Gag and Pol proteins [ 27].
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