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Likewise, we lacked information on singleton or multiple pregnancies, which have different growth patterns.
The continuous development of new assisted reproductive technology has increased the number of twins and multiple pregnancies, which also leads to an increased incidence of PTB.
For examples, new advances in technology have allowed the transfer of two embryos to the eSET preventing multiple pregnancies, which can disadvantage both the mother and the baby [ 63].
The overall proportion of cases from multiple pregnancies which were TOPFAs was lower than singletons at every maternal age, giving an overall maternal age adjusted OR of 0.52 (95% CI 0.41 0.65; Table 4).
Advanced maternal age has also been specifically associated with unexplained stillbirth [ 49, 50], whereas in this study we included all causes of late stillbirth (after exclusion of fetal abnormalities and multiple pregnancies) which may dilute an association between advanced maternal age and unexplained stillbirth in particular.
Moreover, Wcre-mediated loss of E-cadherin did not predispose mice to tumor formation, because none of the Wcre Cdh1 F/F animals developed mammary carcinomas during their live span, even after the induction of multiple pregnancies, which is consistent with previously published studies using MMTVcre and K14cre conditional E-cadherin knockout mice (Boussadia et al., 2002; Derksen et al., 2006).
Similar(54)
Transferring multiple embryos increases risk of multiple pregnancy, which can be risky for both mother and fetuses.
Of these, 13 258 were excluded because of congenital anomaly or multiple pregnancy, which left 92 218 normally formed singleton pregnancies leading to 91 829 live births and 389 stillbirths.
For example, age influences multiple pregnancy, which is itself believed to be a risk factor for caesarean section and blood loss.
39 Though many clinicians consider multiple pregnancy, which is associated with increased maternal and perinatal morbidity and mortality, 1 2 to be the most detrimental effect of assisted reproduction, many infertile couples are not aware of these risks 40 and show a clear preference for twins.
Complications of this therapy include ovarian hyperstimulation syndrome and creation of multiple gestation pregnancies, which can be complicated by preterm labor and delivery, and the associated neonatal morbidity and expense of care for preterm infants.
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