Sentence examples for multiple pathways which from inspiring English sources

Our analyses demonstrate that genomic alterations may affect multiple pathways, which could be classified as drug effector and non-effector pathways by the way they target the two cancer hallmarks 'sustaining proliferative signaling' and 'evading growth suppressors' [21].

This appeared fundamentally different to the EGF-induced EMT, highlighting the multiple pathways which can regulate EMT.

Often, tumor cells have altered transcription factor activity, influencing multiple pathways, which is difficult to target through small molecule drugs.

Essential genes are often implicated in multiple pathways, which can interact to give rise to a disease state [ 65].

Acquired cisplatin resistance is a net result of multiple pathways, which often act simultaneously in a given cell [ 1, 2].

The possible mechanisms of PACs effects on tumor proliferation are complex and are likely to involve multiple pathways, which may differ according to the type of cancer.

Cancer is usually caused by multiple mutations and alterations of multiple signaling pathways which pose an extra challenge when defining the mechanisms underlining cancer development [ 40].

Pharmacological activation of NAD+ thus stimulates the activity of multiple sirtuin in a compartment-specific manner to exert its beneficial effects on multiple metabolic pathways which is in contrast to STAC's that specifically stimulate the activity of SIRT1 pathway.

The major finding from these studies is that AD progression and pathogenesis involve multiple cellular pathways, which suggests that AD is a complex and heterogeneous disease.

DOX-EPNs entered into resistant tumor cells by multiple endocytosis pathways, which resulted in overcoming the multidrug resistance of MCF-7/Adr cells by escaping the efflux induced by P-gp transporters.

Targeting two or more growth signaling molecules may serve to inhibit multiple parallel pathways which are collectively important for cell growth or may inhibit a single pathway more efficiently by suppressing more than one mediator along the pathway.