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Genetic analysis indicates that multiple mutations have accumulated to produce the altered mating preference.
To date, multiple mutations have been identified in patients with various types of hypospadias [1] [3].
Multiple mutations have deleterious effects on functinal importance and breast cancer-related genes (Table 5, Additional file 1: Table S1).
Even within a given population (e.g., East African pastoralists), multiple mutations have been found to explain the lactase-persistence trait.
Multiple mutations have been identified, including missense mutations, mutations affecting splicing, and mutations resulting in truncated WDR62 proteins as a result of premature termination.
In any case, such competition may be more common in the later stages of an experiment when multiple mutations have accrued [ 38].
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Multiple point mutations have been reported and, although the phenotype depends on the specific amino acid alteration, resistance to multiple azoles is common [2], [3], [10], [12] [14].
Although a few instances of multiple somatic mutations have been described for other primary immune deficiencies no WAS patient described at that time had more than one somatic allele (Discussion).
Multiple independent mutations have also been involved in the domestication and improvement of other crops; for example, Vrs1 for the six-rowed phenotype in barley [26] and Phr1 for grain discoloration in rice [2].
Sporadic cases of HPS associated with multiple genetic mutations have also been described [ 13].
Multiple nesprin mutations have been identified that are likely to be included in a multitude of nesprin isoforms.
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