Sentence examples for multiple mutations are from inspiring English sources

However, multiple mutations are often deleterious for the activity and the identification of all the residues that historically led to the function is complicated.

Small size, a well-defined structure, and the ability to maintain structural integrity despite multiple mutations are all desirable properties for such designer proteins.

Single mutations on the helix substantially lowered IGH526 binding but did not affect neutralization, indicating either that multiple mutations are required or that additional regions are recognized by the antibody in the context of the membrane-associated envelope oligomer.

The methodology was developed on the basis of the theories of divergent molecular evolution: (i) enzymes with more active and specialized functions have evolved from ones with promiscuous functions; (ii) this process is driven by small numbers of amino acid substitutions (plasticity); and (iii) the effects of double or multiple mutations are often additive (quasi-additive assumption).

How is change possible where multiple mutations are necessary but intermediate steps have no apparent advantage?

For example, in cavefish, we do not know what is the precise mutation that causes a change in gene expression level, or if multiple mutations are involved.

An additional driver gene mutation increases a cell's fitness by a factor of (1 +s d ), whereas an additional housekeeper gene mutation decreases fitness by a factor of (1 −s h ) and the effect of multiple mutations is multiplicative.

Resistance development for the remaining three drugs required several steps, as multiple mutations were required for resistance above clinical breakpoints.

Two or more mutations were found in 13 patients (18.3%), but multiple mutations were not present in any single viral genome by linkage analysis.

In this study, the bacterial laccase gene (cueO) with single or multiple mutations was directly cloned based on the metagenome of a chemical plant sludge.

The LT cleavage sites for MKKs have been identified [25] and single or multiple mutations were introduced into wildtype MKKs to destroy these sites.