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Multiple mediators of inflammation and injury (ICAM-1, NF-κB, RAGE, PCIII, and E-cadherin) were measured in lung tissue at necropsy, but none were significantly different either within or between groups.
In the absence of multiple mediators of immunity, we hypothesized that the role of neutrophils during influenza virus infection could be studied more effectively.
Multiple mediators of antivascular effects may be involved in providing a selective antitumour effect.
At the molecular level, activation of the transcription factor NF-κB leads to the production of multiple mediators of inflammation.
These matrix fragments can stimulate production of multiple mediators of matrix destruction, including various cytokines and metalloproteinases.
There are likely to be multiple mediators of increased PAI-1 expression of which transforming growth factor-β is a well-studied example.
Similar(51)
The interest of mHLA-DR expression assessment stands in the fact that this marker is a consequence of the effect of multiple mediators on the inflammatory response [21 23].
The likelihood of multiple mediators for knowledge sharing is yet to be investigated.
Indeed, as opposed to circulating molecules, the major advance in measuring a cell surface marker by FCM is that its level of expression is the result of the sum of the effects of multiple mediators, all of which are potentially regulated during septic shock [ 2].
Our model was able to predict the effects of altered pathway components and synergistic combination of multiple mediators, some of which are consistent with experimental findings [ 73].
A detailed comparison of the structures of the core Mediator and its subassemblies, combined with nanogold labeling of multiple Mediator subunits of different modules, suggests that the Head + Middle modules form the upper portion of the structure, while the Tail module forms the dense domain at the base.
Related(20)
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