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Exact(6)
While perioperative blood transfusion (BT) has been associated with adverse outcomes in multiple malignancies, the importance of BT timing has not been established.
For patients with multiple malignancies, the date of the first primary diagnosis was considered the date of initial cancer diagnosis.
Further, two of the previous perianal skin cancer cases were also excluded, one due to multiple malignancies, the other due to histology (Paget's disease of perineum).
Although the biological effects of intracellular zinc and zinc transporters are clearly established in multiple malignancies, the molecular mechanism controlling this phenomenon remains elusive.
For patients with multiple malignancies, the date of the first primary diagnosis was considered as the date of initial diagnosis, and the most advanced stage of any simultaneous primaries was recorded as the stage of disease.
For patients with multiple malignancies, the date of the first primary diagnosis was considered to be the date of initial diagnosis, and the most advanced stage of any primary site was recorded as the stage of disease.
Similar(54)
Hence the possibility of other genetic factors may contribute to the development of multiple malignancies in the Caucasian population.
Another pathway altered in multiple malignancies is the WNT signalling pathway.
MiR-34a, a highly conserved miR has recently emerged as a key tumor suppressor in multiple malignancies through the suppression of multiple targets.
Recent studies have indicated the involvement of Src-homology 2 domain-containing tyrosine phosphatase 2 (SHP2) in multiple malignancies; however, the role of SHP2 in oral cancer progression has yet to be elucidated.
Tateishi et al (2005) showed that the risk of multiple malignancies increased with the age at diagnosis.
Related(20)
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