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When studying multiple cancers, the categorization becomes more complicated.
Although there are other studies investigating associations between genes and multiple cancers, the Mc.TGD is the first embedded approach to conduct "two-dimensional" selection and account for the joint effects of genes in such selection.
Overall, these studies demonstrate that genetic variability within miRNA has the potential to vary miRNA expression and/or mRNA target binding which can be strongly correlated with the onset of multiple cancers, the progression of cancer metastasis and the response to drug therapies.
In the case of activated KRAS2 G12D mRNA overexpressed in multiple cancers, the Tm of the complementary KRAS2 G12D TO-PNA-peptide 12mer with a KRAS2 G12D RNA 20mer was 80 ± 2 °C, independent of the peptide ligand sequence, following the typical behavior of PNA RNA duplexes.
Cancer survivors were identified based on the question: "Have you ever been told by a doctor or other health professional that you had cancer or a malignancy of any kind?" For those who had multiple cancers, the time of first cancer diagnosis was applied to define the primary outcome, quit smoking status at cancer diagnosis.
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From the epidemiological perspective, the main reason for the low frequency of multiple cancers of the esophagus and breast is the gender difference for each cancer type.
The multiple cancers in the study group were more likely to be diagnosed by ultrasound, and were more likely to be multicentric than in the control population.
For the same reason we have not addressed the issue of whether, if there are multiple cancers in the family (including the proband), they are in genetically related women (that is, on the 'same side of the family').
Multiple gastric cancer included multiple synchronous gastric cancers, multiple cancers in the remnant stomach, and the GC patients with the history of prior endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD).
The incidence of multiple cancers of the esophagus and other organs reportedly ranges from 9.5 to 20.7 % [1].
For example, an epimutation of the tumor suppressor gene MLH1 was found in both normal somatic tissues and spermatozoa of a patient with multiple cancers, indicating the potential for transmission of the epimutation to offspring (Suter et al. 2004).
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