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We identified several common haplotypes to be associated with increased BP and multiple low frequency haplotypes significantly associated with lower BP (>10 mmHg reduction) and risk for hypertension (OR<0.60).
This distribution of allele frequencies means that testing the cumulative effects of multiple low frequency coding variants could be used to potentially improve power.
Due to multiple low frequency events and high inter-correlation among adverse outcomes data, variable cluster analysis was performed to develop a smaller number of independent outcomes [ 27].
Namely, the weakly resolved vibronic interval can be explained by the Franck Condon displacement of multiple low frequency modes causing the "valleys" between dominant mode progressions (i.e., the PBTTT CC backbone symmetric stretches, ν3 7) to become filled in.
Importantly, a significant proportion of inherited susceptibility to common disease may be attributable to the effects of multiple, low frequency variants with moderate effects in a number of genes (Bodmer and Bonilla 2008).
Weak clusters of combination bands from multiple low frequency vibrations, likely from thiophene-thienothiophene ring bends and librations, are also apparent before the 0 2 region (∼1700 2500 cm–1).
Similar(52)
Reactive, resistive or hybrid silencers are considered as alternatives with the possibility of adding a supplementary active noise control system to mitigate remaining noise of multiple low frequencies, which are difficult to be attenuated by passive means.
These results strongly suggested that few of the common associations were driven by single or multiple low-frequency variants.
Our data enabled us to largely reject our second main hypothesis that common variant common phenotype associations are explained by individual or multiple low-frequency variants.
This has been made even more important by recent sequencing studies of pancreatic cancer, which have found PDAC to be very complex and contain multiple low-frequency mutations of unknown functional significance.
An alternative explanation for the negative GWAS findings might be that ADHD risk is entirely explained by multiple low-frequency variants that are not well captured by the genotyping arrays.
Related(20)
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