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Histopathological analysis revealed that these fish had multiple large tumors with microscopic features of HCC (supplementary material Fig. S2).
Following repeated injections of CCl4, numerous relatively small tumors appeared in the markedly fibrotic and cirrhotic liver parenchyma, whereas in the DEN model, multiple large tumors developed in the non-cirrhotic background (Fig. 1a).
Endoscopy on day 78 showed that control mice developed multiple large tumors, whereas the number and size of tumors were reduced in the colon of Smad7 antisense oligonucleotide-treated mice.
Most of the control mice developed multiple large tumors in the liver, but pIL-18 gene therapy markedly inhibited tumor growth at 14 days and 21 days after tumor implantation (see additional file 1).
The presence of multiple tumors was determined both by gross examination and palpation of the pancreas since the boundaries between multiple large tumors can be difficult to delineate in hematoxylin and eosin (H&E -stained specimens.
Similar(55)
She presented with abdominal distension and a preoperative CT scan indicated multiple, large tumor foci throughout the abdominal cavity, upon which palliative surgical removal of large amounts of abdominal mucinous tumor tissue was performed.
All PyMT mice, and approximately 50% of PyMT/S14−/− mice in our study formed multiple, large, solid tumors.
Patients who had a T1 tumor, multiple tumors, large tumors (≥3 cm in diameter), or high grade Ta NMIBC received one cycle of intravesical treatment (BCG or mitomycin-C) [26], [32].
26 The issue of patient selection has already been discussed, where surgical intervention is now offered to patients presenting with multiple metastases, large tumor size, and extrahepatic or other underlying liver disease.
When Myc is activated in islets that overexpress an anti-apoptotic molecule, Bcl-xL, β-cell hyperplasia is induced within 7 days and multiple, large invasive β-cell tumors develop after 6 weeks of Myc activation.
Some patients have large tumors or multiple lesions, so the GTVs are large or irregular.
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