The brief article, co-authored by nutrition guru Dr. JoAnn Manson, cites multiple large clinical trials studying multiple nutritional supplements' effects on multiple end points.
With all the irrational talk about the MMR (Measles, Mumps, Rubella) vaccine containing mercury (thimerosal) and being a potential cause of autism (disproven in multiple large clinical trials), there is a far greater risk of measles itself.
Within several years of approval, multiple large safety trials were completed comparing several of these drugs with nonselective NSAIDs.
Pyronaridine has demonstrated activity against falciparum parasites resistant to other antimalarials, and PA has displayed consistently high efficacy in multiple large clinical trials (2).
Similarly, because a strong epidemiologic association exists between even modest levels of hyperglycemia and macrovascular disease in the outpatient population, multiple large-scale trials were undertaken to prove the cardiovascular and mortality benefits of treating diabetics to near-normal A1C (14– 16); the result was no benefit in most cases and perhaps harm (14).
The safety and tolerability of palonosetron has been well documented in multiple, large phase III trials.
> > Multiple, large, prospectively randomized clinical trials have clearly demonstrated that trastuzumab is effective in the treatment of HER2-positive breast cancer in both the early and metastatic settings.
In postmenopausal women with early breast cancer, the third-generation aromatase inhibitors (AIs; anastrozole, exemestane, and letrozole) have been proven to be of value in multiple large well-conducted clinical trials as initial adjuvant endocrine therapy, after several years of tamoxifen, and as extended adjuvant endocrine therapy after about 5 years of tamoxifen [ 1- 8].
Hawton and colleagues [ 11] and Gaynes and colleagues [ 13], noting the limitations of studies with too few subjects and too short a study period, emphasized the need for large trials at multiple sites in order to determine the benefits of interventions.
