Sentence examples for multiple high doses from inspiring English sources

The study started in July 2015, and initial administrations of the drug produced no severe side effects; things went wrong in a group of eight people who entered the study on 6 January and received multiple, high doses.

Antibody cocktails including 2G12 have proven able to reduce the rate of viral rebound after ending antiretroviral treatment in some human patients [20], but the use of these cocktails requires multiple high doses.

This suggests that administration of multiple high doses of systemic 4-hydroxytamoxifen is capable of penetrating the tumor tissue to enable Cre-ERT2-mediated recombination of loxP sites.

CVN was also able to delay death due to EBOV challenge in a murine model, although this required multiple high doses.

Importantly, these titers were comparable to those achieved by multiple high doses of current candidate vaccines that contain no adjuvants and are administered via non-oral immunization.

Despite exposing the pups to multiple high doses (2 × 10−10 CFU per gavage) before weaning, the mice developed hyper-IgE at adult age.

The patient received multiple high dose chemotherapy regimens followed by surgery.

Recording of the patient's dose exposure is mandatory and measures should be in place to recognise patients requiring multiple high dose exposures (eg, computed tomography pulmonary angiogram (CTPA) followed by PCI).

14 19 21 27 To assess the presence of a dose-response effect, we did a sub-analysis on studies that included effect estimates for frequent or multiple (high dose) exposures to indoor tanning (table 3, top).

Despite considerable research efforts, the treatment of TB continues to be a great challenge in part due to the requirement of prolonged therapy with multiple high-dose drugs and associated side effects.

This suggests that, under given parameter values, even multiple, high-dose local administration of the virus to accessible tumors (a usual clinical practice) will be ineffective.