Exact(2)
As DNA-sequencing costs plummet, other biomedical projects analyzing multiple genomes have sprouted up, but Durbin believes the Wellcome Trust one is at the "top end of what people are doing".
Current models, based on global-level analyses of domain combinations in multiple genomes, have suggested that the propensity of some domains to associate with other domains in high-level architectures increases with organismal complexity.
Similar(6)
With sequencing of complete genomes and development of comparative genomic methods, extensive analysis of a complex regulatory system in multiple genomes has become possible.
Previously, anchor identification among multiple genomes has been achieved using pairwise alignment tools like BLASTZ through progressive alignment tools like TBA, but the computational requirements for sequence comparisons of multiple genomes quickly becomes a limiting factor as the number and scale of genomes grows.
The prediction of functional linkage between the genes involved in several metabolic pathways across the multiple genomes has been demonstrated to correlate functional with physical linkages of gene clusters [ 25].
Once multiple eukaryotic genomes have been sequenced, such genome-wide evolutionary reconstruction has become realistic.
Multiple chromosome genomes have been described and appear to have evolved independently in at least five different bacterial clades [ 31, 76- 79].
Multiple insect genomes have been sequenced, with many of them having annotated immune genes, which paves the way for a comparative genomic analysis of insect immunity.
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