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This study aimed to determine the comparative efficacy of a single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection.
Lyimo et al.: Efficacy of single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection: study protocol for a randomized controlled trial.
PK parameters (overall and by histology) following a single dose (cycle 1 day 1), and mean Ctrough values after multiple doses for dose‐compliant patients (Supporting Table 3) were consistent with those previously reported.
However, in the case of drug testing with multiple doses for each drug, plates are often made from serial dilutions and thereby the plate with the highest concentration of drugs will contain rows and columns with many hits.
For multiple doses, for the time interval 13 60 h, the 97.5th percentile was underpredicted, which may be explained by the small amount of data (six concentration observations), including one at a significantly higher concentration than the others.
Similar(55)
The mean plasma half-life of luseogliflozin (T1/2) after multiple dosing for 7 days ranged from 9.14 to 10.7 h, and no detectable accumulation of luseogliflozin was observed.
The geometric mean ratios of Cmax after multiple dosing for 21 to 22 days (last dose/first dose) for patients on the 135 mg and 200 mg MK-2206 QW dosing schedule were 1.26 and 1.30, respectively.
The steady-state plasma PK parameters following BID multiple dosing for 28 days included Cmax ss, tmax ss, observed trough concentrations of drug during the dosing interval (Cmin ss), t1/2 ss, AUCss, CLss/F, accumulation ratio (Rac) and temporal change from single dose to steady state (Tc; often referred to as linearity factor).
The ability to administer multiple doses of mAb for either therapy or imaging has not been a trivial consideration in the management of cancer patients.
Most patients had multiple doses of quinine (for 24 to 48 hours) combined in a single 500 ml bottle of 5% dextrose.
Multiple doses of luseogliflozin for 7 days did not increase the frequency or severity of AEs.
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