Similar(8)
The cumulative results of this evidence-based review and numerous meta-analyses indicate that once-daily dosing strategies generally result in less AKI when compared with multiple-dose dosing strategies, although the benefit accrued by the single-daily dose strategy is modest and inconsistent across a number of these studies.
The study was a single-blind, placebo-controlled, multiple-dose, dose-escalation study of LY450139 conducted in a combined inpatient/outpatient fashion [ 14].
Randomized, double-blind, placebo-controlled, singledose and multiple-dose dose escalation studies have evaluated the pharmacokinetics, safety, and tolerability of dolutegravir in different cohorts of healthy subjects (for a total of 50 healthy volunteers).
This was further supported by a multiple-dose, dose-ranging study by Kanniess et al 18 and a 28-day safety study by Chuchalin et al. 19 Finally, indacaterol 200 mcg was also superior to salbutamol 200 mcg and salmeterol 50 mcg in a single-dose study in persistent asthmatics 20 Peak bronchodilation in these studies was observed between 2 4 hours postdose.
RIPC: Remote Ischemic Preconditioning, SD: Single Dose, MD: Multiple Dose.
Due to ease of administration in a multiple dose situation, oral dosing of the nanosuspension was examined initially.
However, the poor aqueous solubility of DCU poses a challenge for in vivo dosing in a multiple dose situation.
Both protocols developed so far, the single dose and multiple dose antagonist protocol, are comparable, utilizing data from the large prospective phase IIIb studies.
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