Sentence examples for multiple dose administration from inspiring English sources
A dosing interval of 48 h prevented piroxicam accumulation following multiple dose administration.
The results suggested that multiple dose administration of Danshen capsules could induce cytochrome P450 (CYP) isoenzymes, thereby increasing the clearance of clopidogrel.
The duration of CCR5 receptor occupancy appeared to be dose-dependent and associated with antiviral activity as measured by plasma human immunodeficiency virus RNA nadir following 10 days of multiple dose administration.
Such studies are becoming more and more common, EMA writes; for instance, the trial in Rennes included subtrials using single and multiple dose administration, as well as trials on drug interactions with food and on pharmacodynamics, the study of a drug's biochemical and physiologic effects on the body.
Multiple dose administration of brodalumab was tolerated in subjects with active RA.
The bioavailability of gabapentin is not affected by the presence of food and remains unchanged following multiple dose administration.
MO did not show any effect in normoglycaemic rabbits either in single or multiple dose administrations, but a good hypoglycaemic activity was observed 4 h after the administration to diabetic animals at 50 mg/kg.
15 In fact, pharmacokinetic studies observed an increase in Cmax with concomitant intake of a high-fat meal (24% after a single dose administration and about 20% after multiple dose administrations), but there was no significant change in overall area under the curve (AUC0 24 hours).
Chow, H. H. et al. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals.
To assess whether success rate differs in single-dose versus multiple-dose administration of methotrexate (MTX) in medical management of unruptured ectopic pregnancies.
A multiple-dose administration regimen of MA significantly increases PKCδ expression, while rottlerin, a PKCδ inhibitor, significantly attenuates MA-induced hyperthermia and behavioral deficits.
