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Immunotoxins have been difficult to produce in eukaryotic systems, because due to their nature they kill eukaryotic cells, and production in bacteria has had limited success because prokaryotes are unable to fold multiple domain proteins.
There are two sub-families of pro-apoptotic proteins with one sub-family consisting of multiple domain proteins (Bax, Bak, Bod) and the other sub-family consisting of BH3 domain-only proteins (e.g., Bim, Bad, and Bik)(reviewed in [17]).
We find 11 new multiple domain proteins.
FPfam obtains less single-domain proteins and more multiple domain proteins than Pfam.
Overall functionality and efficiency of multiple domain proteins are affected by linker sequences.
These basic cassettes can then be recombined in any order and number of times to create fusion cassettes of multiple domain proteins.
Similar(50)
Tap is a multiple domain protein composed of a Lotus domain and three Tudor domains.
As a multiple domain protein, CheA has an central role in our models.
CUB and Sushi multiple domain protein 1 (CSMD1) is a candidate tumour suppressor gene of unknown function.
A notable example within the Hymenoptera was N. vitripennis (parasitoid wasp), which contains a single 7DMA protein only, the most significantly expanded multiple domain protein aside from the previously described 8DMA protein of Tr. ca staneum (Fischer et al. 2008).
Both have homology to a large multiple domain protein in Wolbachia endosymbionts of Culex pipiens (e.g., WP_007302981.1) that has a latrotoxin domain at its C-terminus and numerous ankyrin repeats in the N-terminal half.
Related(20)
multiple domain environments
multiple domain hits
multiple domain occurrences
multiple domain matrices
multiple domain fragments
multiple domain assemblies
multiple domain experts
multiple domain types
multiple domain calculations
multiple domain groups
multiple domain ontologies
multiple domain rearrangements
multiple domain structures
multiple domain aMCI
multiple domain systems
multiple alignment proteins
multiple domain methods
multiple domain architectures
multiple domain interactions
multiple domain names
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