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In a similar analysis testing the independent relationship between CCS, as dependent and continuous variable, baseline adiposity measures such as, WHR, WC and total fat mass values were independent determinants after adjusting for baseline CCS and multiple confounders in DM patients(Table 3).

It thus includes those multiple confounders in its frame of reference.

The sample size was small, which limited the ability to control for multiple confounders in regression analysis and also limited power to detect small changes in pCO2.

The presence of multiple confounders in the study design make these discrepant results difficult to interpret, and importantly, most studies lacked any measurement of serum or urine chromium levels.

In many of these studies, sample sizes and multiple confounders in case definition limit definitive interpretation, leading some authors to conclude that socio-economic factors are mainly responsible for the variation in school performance and neurocognitive ability in asthma [ 32].

While our study has many strengths including the ability to adjust for multiple confounders in a large, nationally-representative sample of U.S. children, there are several limitations to this study that warrant consideration.

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In addition, multiple confounders assessed in our statistical models have plausible association with both depressed mood and LBW in both our study sample and the overall population.

While the statistical models used in this analysis have accounted for multiple confounders identified in the literature to date there is always the possibility that there may be other confounders hitherto unknown.

Few studies (26%) reported results adjusted for multiple confounders, and in seven studies (37%) no type of adjustment was mentioned.

It is hoped that the preceding description of studies in India will spur the creation of new international networks to undertake studies that would have the ability to provide tangible evidence, duly address multiple confounders, assist in intervention design/evaluation, and create baselines for future follow-up.

Admittedly, patient characteristics differed between zones, but also after adjustment for multiple confounders, seasonal variations in mortality were only significant in the temperate zones, although this.

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