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Exact(4)
This indicates that our kinome dataset contains a wide range of kinases, including those that are promiscuous to multiple compounds as well as selective kinases.
Overall, by using multiple compounds as "baits" to fish out more active compounds against a given target from a database of decoys, this simple but efficient approach for target enhanced similarity search is promising for chemical database screening.
Majority of plants contain multiple compounds as active ingredients, which are frequently used in drugs.
When the library identified multiple compounds as matches, careful consideration of the spectra yielded one with much higher similarity or a determination of "unknown" was made.
Similar(56)
These calculations thus can become time-consuming in applications where one wishes to process multiple compounds, such as a commercial compound catalog.
Complementary action of multiple compounds could increase efficacy as well as reduce side-effects through pharmacological interactions.
In fact, therapies based on coordinated actions of multiple compounds have been used as early as the dawn of medicine.
Multiple compounds were identified as potent HDAC inhibitors (HDACi), with IC50 values in the low nanomolar (nM) range against enzyme activity in HeLa cell extracts and sub-μM for their in vitro anti-proliferative effect on cell lines.
Although this may argue against a possible in planta DON-inducing role for this metabolite, it should be noted that the actual putrescine concentration at the host-pathogen interface may be higher than the overall tissue level and it is possible that DON is synergistically induced by multiple compounds and conditions as demonstrated previously [ 15, 18].
This indicates that our kinome dataset contains both kinases that are promiscuous to multiple compounds (e.g. > 40) as well as selective kinases (e.g. < 20).
The presence of multiple compounds in natural products such as SCS can provide the advantage of acting on multiple pathways that control the process of cancer development and progression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com