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Differentiation based on PK profiles in multiple species as well as activity in a chronic efficacy model led to the identification of 1 (CC-930) as a development candidate, which is currently in Phase II clinical trial for IPF.
Dunn, Luo, and Wi (2013) extensively reviewed the utility of comparative expression across multiple species, as well as its challenges.
MALS data are also consistent with multiple species as indicated by a broad peak eluting from the prior gel filtration chromatography column, with masses ranging from 267 kDa (peak2) to 332 kDa (peak1) (Fig. 1H).
The majority of groups analyzed were for a single species rather than multiple species as done for SAG.
When multiple species are used, as in this analysis, pairwise homology maps can be utilized to build orthology maps for multiple species, as Mercator will find orthologous segments even if some anchors are missing in one of the species.
Vertical descent with modification can be taken to underlie various taxonomic projects: the classification of organisms into a particular species; the classification of genes into functional categories (Tatusov et al. 2001); stabilization of sets of metabolic capacities to classify entities with specific impacts on geochemical processes, for example multiple species as denitrifiers; and so on.
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That number ballooned to 15,000 species when the team discovered, through the use of DNA typing, or "bar coding," that many of the species were actually made up of multiple distinct species, as many as 11 in one case.
An intron is present at the same location in FoxO genes from multiple other species, as well as in members of some other Fox gene families [25].
Influenza B predominantly circulates in human populations, in contrast to influenza A, which circulates in multiple animal species as well as in humans.
Indeed, based on a conserved ratio of centromere and kinetochore proteins and kinetochore microtubules between multiple yeast species as well as chicken DT40 cells, it has been hypothesized that centromeres form modular structures by repeating individual structural subunits (Joglekar et al., 2008; Johnston et al., 2010), as originally proposed by Zinkowski et al. (1991).
Although sarcospan is proposed to have important roles in modulating the stability of other components of the DGC, the absence of a sarcospan from T. adhaerens and multiple cnidarian species, as well as its absence in Drosophila (Greener and Roberts, 2000), indicates that it has been dispensable in many invertebrates.
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