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Perhaps the premier challenge for formulating appropriate mathematical models is the complexity of signaling networks, especially due to formation of multiple complexes and many different post-translation protein modifications.
The latter effect is stronger for proteins associated with multiple complexes and for those binding early during complex self-assembly, including proteins that oligomerize with large proportions of surface buried.
In reality some proteins exist in multiple complexes and this discrepancy could bias our results.
The set of complexes defined by Gavin et al. [ 9] which we used to perform our analyses is much larger with many proteins belonging to multiple complexes and thus allows to test the statistical significance of observations.
Genes coding for proteins that are present in multiple complexes and therefore form a high number of interactions tend to evolve more slowly and seem to be more conserved than genes coding for proteins with few interactions, however the magnitude of difference was not dramatic [ 19, 23].
We studied a first cohort of 30 patients with cardiomyopathy and a biochemical defect of the MRC, affecting either CI alone or multiple complexes, and a second small group of four cases with isolated CIV deficiency and at least one affected sibling, irrespective of their clinical presentations (ranging from cardiomyopathy to encephalopathy).
Similar(54)
The forces in history are always multiple, complex, and contingent, much more so than the fables make it seem.
Multiple, complex and interacting damage mechanisms occurred even at very low incident energies.
Mr Drakeford told AMs: "It [the McLelland review] found that the fundamental problem has been that current accountability and governance arrangements for ambulance services in Wales are multiple, complex and lacking in clarity and sympathy.
Altogether, these data suggest that the regulatory apparatus of the pou3f4 is multiple, complex and integrate distinct developmental inputs.
The daily environmental assaults posed to normal pulmonary and cardiovascular cells can exert multiple, complex, and often interconnected stress responses.
Related(20)
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multiple communities and
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multiple combinations and
multiple sites and
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multiple blocks and
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