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First, multimodal therapy of MB patients includes not only alkylating agents but also other cytotoxic drugs and radiotherapy.
Although significant improvement in diagnosis and multimodal therapy of esophageal cancer has been made, this cancer entity is still associated with an unfavorable prognosis.
Second, despite of usually limited survival of patients with PNS associated with onconeural antibodies, long-lasting stabilization of neurological symptoms can be achieved by effective multimodal therapy of the underlying malignancy.
3 5 Despite great progress in surgery and multimodal therapy of non-metastatic tumours, local control and limb salvage remain major challenges in large, high-grade or recurrent tumours.
Our data show that induction of apoptosis and inhibition of hedgehog signalling are important features of the anti-tumourigenic effect of BA in RMS and advices this compound for the use in a multimodal therapy of this highly aggressive paediatric tumour.
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Finally, 5AR inhibitors have been studied as a component of multimodal therapy for all stages of prostate cancer, with the goal of improving oncologic outcomes while avoiding the toxicity of medical and surgical castration.
The addition of celecoxib to fish oil modulates eicosanoid metabolism, reducing symptoms of secondary syndromes in cancer (Cerchietti et al, 2007), in particular those associated with inflammation, and provides a strong argument for the use of fish oil as part of a multimodal therapy for the treatment of these conditions.
Finally, while preliminary data indicate a possible role of 5AR inhibitors in various forms of multimodal therapy for prostate cancer, there have been no definitive studies demonstrating improved survival with its use in any regimen.
To compare the efficacy of 2 chemotherapeutic drug combinations as part of multimodal therapy for orbital retinoblastoma.
Although gemcitabine (GEM -based chemotherapy has formed the core of multimodal therapy for pancreatic cancer (Oettle et al, 2007), it is rarely curative and only modestly effective aGEM -basedour rechemotherapy
For ADHD treatment, a multimodal therapy consisting of medication and behavioral treatment is recommended [6].
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