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Successful e-health programs involve frequent communication, bidirectionality including feedback, and multimodal delivery of the intervention.
Specifically, we review the strategies for rationally designing nanoparticles for targeted, multimodal delivery of therapeutic agents.
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The result is a construct with a higher level of structural complexity (a fibrous mesh with embedded spheres) and functionality (multimodal delivery).
Nanotechnology platforms can provide the unique niche within this space by enabling multimodal delivery with a single application.
The IMS-based mashup framework firstly supports the combined delivery of multimodal services based on CAM4Home model.
As a result, the modern ICU has evolved into a highly specialized unit designed to facilitate rapid diagnosis, continuous monitoring, and prompt delivery of multidisciplinary, multimodal, and technologically advanced therapies [ 13].
Using such a platform, we verified tumor-targeted delivery of MSCs by in vivo multimodal imaging in an orthotopic U87MG glioblastoma model, displaying higher tumor uptake than particles without MSCs.
Here we describe a mesenchymal stem cell (MSC -based MSC -basedional platformultifunctionalhotoplatformblastoma by intargeting the tumorthotopicd delivery of mesenchymal stem cells and the multimodal imaglioblastomage of mesoporous silica nanoparticles (MSNs).
In particular, we demonstrate applications of UCNPs as a new nanoplatform for optical and multimodal cancer imaging in vitro and in vivo and extend discussions to delivery of UCNP-based therapeutic agents for photodynamic and photothermal cancer treatments.
A high labeling yield of DTPA-SPION MBs as well as their suitability for multimodal imaging SPECT/CT/MRI favor these MBs for further studies as a candidate for drug delivery of cytostatics and imaging of cancers such as lung cancer, HCC, or metastasis.
In addition, platforms for the delivery of these and other drugs will be reviewed including antibody-drug conjugates, micro- and nanoparticles, and multimodal hydrogels.
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