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However, further studies are needed to establish the effect of intensified multifactorial treatment on DN with overt proteinuria.

The effects of intensive multifactorial treatment on PROMs among people with type 2 diabetes mellitus detected by screening are not known.

This study is the first examining the effect of intensive multifactorial treatment on central hemodynamics among individuals with screen-detected diabetes in general practice.

In addition, multifactorial treatment on risk factors, including weight control, lipids, blood pressure, and glucose level lowering, in patients with type 2 diabetes is a difficult task [ 51], especially for patients with pre-existing cardiovascular diseases [ 52].

The effect of intensive multifactorial treatment on central hemodynamics was analyzed by mixed-effects models with adjustment for clustering (randomization by general practice) and heart rate at time of measurement, taking its direct functional effect on the hemodynamic markers into account.

Similar(55)

To our knowledge, no studies have examined the effect of multifactorial treatment of cardiovascular risk factors on aortic stiffness.

Intensive multifactorial treatment of screen-detected diabetes during 6 years in general practice has a significant impact on aortic stiffness, whereas the effects on other hemodynamic measures are smaller and not statistically significant.

All patients received multifactorial treatment for the prevention of CAD.

Finally, if the presence of atherosclerosis and/or dysfunction in different territories are correlated in type 2 diabetic patients that receive intensive multifactorial treatment, aimed on CV prevention, is not known [ 6].

We now report the effects of intensive multifactorial treatment compared with RC on self-reported health status, well-being, diabetes-specific quality of life and treatment satisfaction.

We examined the effect of intensive multifactorial treatment in general practice on indices of peripheral and central hemodynamics among patients with screen-detected diabetes.

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