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Human disorders attributable to multifactorial inheritance alcoholism Alzheimer disease cancer coronary heart disease diabetes epilepsy hypertension obesity schizophrenia About 1 out of 150 live newborns has a detectable chromosomal abnormality.
Most primary headaches have multifactorial inheritance and a precise description of the pathogenesis is lacking.
It is expected that identification of genetic markers will be difficult due to multifactorial inheritance.
Migraine has a strong (up to 50%) genetic component with a probable multifactorial inheritance [5].
A complex segregation analysis of chronic tension-type headache suggests multifactorial inheritance without generational differences [22].
Currently, migraine is widely considered a complex disease with multifactorial inheritance.
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Apart from this, family studies have provided evidence that there is a genetic predisposition to DDH based on polygenic-multifactorial inheritance [ 7].
Migraine is a common neurovascular disorder with multifactorial and polygenic inheritance.
The most consistent explanation for this is a multifactorial pattern of inheritance, implicating a combination of genes and environment.
For both disorders, oligogenic and multifactorial modes of inheritance have been proposed, but relatively little progress has yet been made in identifying the genes involved [ 31, 33].
We propose a polygenic or multifactorial form of inheritance in the undiagnosed group, whereby affected genes in combination with other adverse genetic and/or environmental factors may exceed a critical threshold for phenotypic manifestation.
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