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Recent studies have indicated that BBR may be also effective in treating chronic, multifactorial diseases, including diabetes, hyperlipidemia, heart diseases, cancer, neurological disorders, and inflammatory diseases [ 172, 173].
It is therefore not surprising that a similar attitude has influenced also etiological research in multifactorial diseases, including multiple sclerosis (MS).
Single-gene disorders tend to be rare, whereas many important multifactorial diseases, including, for example, hypertension, diabetes and schizophrenia, have much higher frequencies in the population, but still have high heritabilities.
Recent studies have revealed that genetic variants in 9p21 are associated with multifactorial diseases, including coronary artery disease, type 2 diabetes, malignant melanoma, basal cell carcinoma, nevi (moles) and glioma [ 66- 69].
This period (approximately 1985 to 1995), which can be regarded as the first wave of stroke genetic research, was also the beginning of susceptibility allele research for numerous other multifactorial diseases, including ischemic heart disease, type 2 diabetes and metabolic syndrome.
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Potential applications of genetic profiling in multifactorial diseases include tailoring of prevention programs to at-risk individuals, determining the starting age of participation in screening programs [ 4] and, when profiles predict treatment success, tailoring treatment modalities and starting doses.
Type 2 diabetes is a multifactorial disease including genetic and many other environmental factors.
Cancer is multifactorial disease including genetic and metabolic alterations.
In fact, IRI is a multifactorial disease including oxidative stress, inflammation, proteasome activation, endoplasmic reticulum stress, mitochondrial damage, and cytoskeleton alterations which lead to cell death and organ dysfunction [ 22– 22].
Although the etiology of anemia is complex and multifactorial, parasitic diseases, including malaria and intestinal parasites are recognized as the major cause of anemia in endemic countries [32], [33].
The power of the KD4V approach has also been demonstrated in a number of recent studies devoted to specific human diseases, including multifactorial diseases (complete congenital stationary night blindness).
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