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Use of such multifactorial models, including interactions, may pave the way to prediction of diabetic nephropathy and other complex genetic diseases in other populations.
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Penn et al. [ 1] argued that multifactorial models of schizophrenia, including only non-social cognitive processes i.e. 'neurocognition', did not adequately explain the social functioning impairment in schizophrenia.
Using a polygenic animal model including ENU mutagenesis provides an efficacious approach to explore the relationship of variants to behavioral phenotypes associated with polygenic and multifactorial disorders such as psychiatric disorders.
However, Radloff (1977) argues against undue emphasis on separate factors and suggests using a simple total score to measure depressive symptomatology, so multifactorial models could be more justified if they include a higher order construct.
In terms of etiology, although the vitamin D deficiency hypothesis remains the most plausible mechanism for postoperative ePTH, other hypotheses including a multifactorial model are still possible given the interrelationship of these factors.
In our multifactorial models, we also observed that the association between sex and head injury corollaries varied by injury mechanism.
In multifactorial models this association was no longer significant.
The major gene model was favoured, and the sporadic and multifactorial models were strongly rejected.
Contrary to that study, multifactorial models were finally used to predict the case-control status.
Other studies have used extensive multifactorial models, most of them focusing on a few BRCA1 UVs.
Such findings support the multifactorial model of gastric pathology that includes the host, H. pylori, and the environment [ 13, 36, 39].
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