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Many variances of the Monte Carlo method which require much reduced sample sizes are available such as Latin hypercube sampling, orthogonal array sampling, adaptive importance sampling and generalised antithetic sampling.
At a regional level, GLF estimates are prone to more error due to much reduced sample sizes and confidence intervals are so wide, as demonstrated in Figure 1, that changes from year to year will be difficult to detect; therefore the large sample size in THIN is extremely valuable.
Before the present study, only few others had evaluated FISH in the classification of renal cortical neoplasms in needle biopsies but with much reduced sample numbers and assessing fewer genomic aberrations 33, 35.
(In evaluating the effects of additional adjustment for confounders in model 3 compared with models 1 and 2, the much reduced sample size consequent on use of model 3 should be considered in interpreting these non-significant results).
Despite a much reduced sample size, these post-hoc analyses revealed that at the ages of three and six months, which are characterized by rapid Aβ plaque formation, those CRND8 mice which showed more Aβ plaques, also showed higher tone fear memory.
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Although many diversity analyses employed in biological assessments are of high-quality and credibility, the limited identification capacity may lead to coarse diversity resolution [ 10], inconsistent taxonomic delineation across individual researchers and institutes [ 11], much reduced sampling scale [ 7], and extended turn-around time in routine sample processes [ 12].
This result was in accordance with ours, even though we used a much simpler purification process that saved time and significantly reduced sample loss.
We are developing new approaches based upon Structures for Lossless Ion Manipulation (SLIM) that aim at enabling much more complex sequences of ion manipulations in one platform, with potential advantages that include greater speed and reduced sample size requirements.
The 2005 cohort appears to be relatively much reduced in samplings from fall 2006, despite similar sampling effort and catchability (data not shown).
The statistical power to detect differences was much reduced when 3 samples per group were analyzed instead of 4. The 2 μg samples and the matched 10 μg samples were able to detect 83 86 differences at p ≤ 0.01 as compared to 150 differences when using all of the 10 μg samples.
This increase in overall genetic differentiation is significant and indicates that even in species highly diversified genetically such as spruces and even at an early stage of domestication, a sample of much reduced size resulting from high selection intensity can lead to increased genetic differentiation.
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