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FL-HSCs have a much higher proliferative capacity for long-term repopulation than HSCs from BM or umbilical cord blood and acquire adult characteristics in mouse BM between 1 and 2 weeks after birth[8] [9].
A major difference between primary myeloma samples and myeloma cell lines is the much higher proliferative capacity of the latter.
Considering the fact that children's eyes exhibit a much higher proliferative potential, long-term results in adults may be even better.
When PEC proliferation was stimulated by testosterone, a much higher proliferative response was observed in p27+/- and p27-/ than in p27+/+ mice, indicating that p27Kip1 lack or haplo-insufficiency increases the sensitivity of PEC to hormone stimulation.
Diploid tumor cells have a much higher proliferative activity than tetraploid tumor cells, suggesting that the latter may possess a limited growth potential that makes abrogation of binucleation proliferatively advantageous.
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The incidence of proliferative diabetic retinopathy was much higher in subjects with mild non-proliferative diabetic retinopathy (5.2%) and moderate non-proliferative diabetic retinopathy (29.4%) in the first survey.
In a pooled analysis of over 6000 patients enrolled in seven prospectively conducted neoadjuvant trials, rates of pCR were much higher among patients with more highly proliferative tumours, including the HER2-enriched and triple-negative subtypes compared with hormone receptor-positive subtyes (von Minckwitz et al, 2012).
In the present PET study of a mouse tumor model, as shown in Fig. 5, although the maximal SUV of [11C]AZT in tumor tissue was less than that of [11C]4DST, the accumulation of [11C]AZT in tumor tissue was much higher than that in the abovementioned normal proliferative tissues.
During EAE, astrocytes form a scar that surrounds the blood vessels and mice with targeted ablation of proliferative astrocytes exhibit a much higher number of leukocyte infiltrations in the CNS parenchyma [ 141].
However, the level of apoptosis that we observed does not fully account for the much higher difference in the viable cell numbers, suggesting that miR-181c is also having an anti-proliferative effect which could be mediated through p53 and PCAF (Figure8).
(Much higher).
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