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As stem cells are a continually self-renewing population, whereas osteoblasts are much less proliferative, control of growth may be a crucial step in moving away from the stem cell phenotype.
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Several studies have been devoted to the evaluation of environmental and genetic factors related to DR and proliferative DR (PDR), whereas much less is known about epigenetic mechanisms [ 3– 7].
Luminal A and luminal B subgroups of oestrogen receptor-positive tumours have also been described, but the separation of these two groups is much less defined with the biology being largely a continuum from low proliferative luminal A tumours to highly proliferative luminal B tumours.
Although PRs are present in epithelial cells at puberty, the pubertal mammary gland is much less responsive than the adult mammary gland to the proliferative and alveologenic actions of progesterone [ 2].
The differences between proliferative endometrium and endometrioid tumour-adjacent tissue are much less pronounced.
Conventional view supported the idea that malignant cells are much less dependent on Ca2+ during the proliferation than healthy cells, and even loss of proliferative dependency on Ca2+ was considered as a hallmark of malignant transformation (reviewed in [ 56]).
Much, much, much, much less perfect.
How much less?
Much less appalling.
God, much less bigotry.
Eat out much less.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com