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It is not known how many olfactory receptor neurons should be intact to maintain olfaction in mouse models treated with 3-methylindole.
55 Experimental data from prepubertal and adult mouse models treated with cyclophosphamide do not support the notion that a prepubertal stage would be protective for the primordial follicles.
In our prior studies in patient-derived xenograft mouse models treated for short period of time, we observed an almost complete elimination of cancer stroma (Von Hoff et al, 2011).
In mouse models treated with a bile acid sequestrant, it has been proposed that the increased synthesis of bile acids via the CYP7A1 pathway increases entry of natural TGR5 agonists (such as cholic acid and cholic acid derivatives) into the systemic circulation.
Chai et al. were intrigued by the bone loss and increased osteoclast formation observed in mouse models treated with the geldanamycin-derived HSP90 inhibitor and anticancer drug 17-AAG and demonstrated an HSF-1-dependent increase in differentiation upon 17-AAG treatment.
The authors claim that "Experimental data from prepubertal and adult mouse models treated with cyclophosphamide do not support the notion that a prepubertal stage would be protective for the primordial follicles", citing their own abstract 2 which is not indexed in PubMed and cannot be evaluated.
Similar(54)
A mouse model treated with carbon tetrachloride (CCl4) was used as a model of liver fibrosis.
No obvious side effect was observed in the mouse model treated by anti-Cripto Mab.
They went on to demonstrate in vivo tumour growth repression in a mouse model treated with a miR-21 inhibitor.
These results are in accordance with those reported in the K-RAS conditional mutant mouse model of lung ADC treated with sunitinib (Gandhi et al, 2009) and in the urethane mouse model treated with DC101 (Karoor et al, 2010).
Given the fact that Leu et al. could show a reduced tumorigenicity in an Eμ-Myc-transgenic mouse model treated with PFT-μ over several weeks, the inhibitor seems to be applicable in an in vivo setting.
Related(20)
rat models treated
vitro models treated
murine models treated
mouse models characterized
mouse models categorized
mouse macrophages treated
mouse osteoclasts treated
mouse lungs treated
mouse models examined
mouse neutrophils treated
mouse xenografts treated
mouse podocytes treated
mouse islets treated
mouse cells treated
mouse kidneys treated
mouse embryos treated
mouse retinas treated
mouse follicles treated
mouse wounds treated
mouse preadipocytes treated
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