Sentence examples for mouse models characterized from inspiring English sources

The bioluminescent mouse models characterized here could serve as important tools for biomedical research.

Among AD animal models, TgCRND8 mice showed a more extensive spectrum of synaptic alterations compared to other AD mouse models, characterized by mutations only in the APP gene (APP23 and Tg2576 mice).

The KID and KIR mouse models characterized here will help to better understand the long-term effects of IGF1 supplementation as well as the potential impact of free IGF1 on neoplasia and health or lifespan.

Transgenic mouse models characterized by conditional expression of the simian virus 40 T antigen oncogene in postmitotic neurons clearly presented a neurodegenerative phenotype, consequence of forced cell cycle activation [ 32].

We tested this hypothesis on three recombinant mouse models characterized by defective cytochrome c-oxidase (COX) activity: a knockout (KO) mouse for Surf1, a knockout/knockin mouse for Sco2, and a muscle-restricted KO mouse for Cox15.

Our results are concordant with very recent works reporting beneficial effects of NAD+ precursors in mouse models characterized by reduced NAD+/NADH ratio, such as aging (Gomes et al., 2013) or complex I deficiency (Karamanlidis et al., 2013).

Using a transgenic mouse model characterized by CNS hypermyelination, we show that larger myelin content results in greater severity of experimental autoimmune encephalomyelitis attributable to an increased number of microglia within the hypermyelinated brain.

The humanized mouse model characterized in this paper may facilitate the study and understanding of the functions of the human CYP2C enzymes.

To assess the potential role of transforming growth factor beta (TGF-β) overactivity in driving these cardiovascular abnormalities, we studied a novel transgenic mouse model characterized by ligand-dependent activation of TGF-β signaling in fibroblasts.

Samuele De Minicis (Università Politecnica delle Marche, Ancona, Italy) demonstrated the role of fibrosis as a cofactor in a new mouse model characterized by the evolution of NASH to liver cancer.

As in human, the phenotype of the deletion mouse model depends on the parental origin: paternal or maternal inheritance of the Tg-deletion, respectively, results in the TgPWS mouse model characterized by severe neonatal hypoglycemia and early lethality [ 9] or in TgAS mice with a mild neurobehavioral phenotype and late onset obesity [ 7].