Sentence examples for mouse models clearly from inspiring English sources

In addition, mouse models clearly indicate that different strains can show highly variable responses to bacterial challenge [ 20].

The Flores and Romano mouse models clearly indicate that ΔNp63 is indispensable for normal epidermal development and stratification.

These observations as well as an abundance of data from mouse models clearly establish CD40/ CD40L as central pathway required for humoral immune responses.

Despite considerable homology between Crk II and CrkL in their SH2 and SH3 domains, development of knockout mouse models clearly show these gene products have distinct, non-overlapping roles, during embryonic development as both Crk knockout and CrkL knockout mice die perinatally with different developmental defects.

For example, while available mouse models clearly indicate a predominant role for Fig4 in neurons, the onion bulbs and active demyelination/remyelination observed in CMT4J patient biopsies would be consistent with a cell autonomous role for FIG4 in Schwann cells as well (6– 8).

Hence, the Ltbp3 −/− mouse model clearly recapitulates the AI phenotype observed in our patients.

Our PCa mouse model clearly demonstrated that increased CCL2 and EMT markers in AR silenced PCa cells were associated with increased distant metastasis, in spite of reduced size of orthotopic AR silenced primary tumours.

Genetically manipulated mice models clearly demonstrate that ER stress and UPR influence insulin signaling and glucose homeostasis (Table 1, Figure 1(a)).

Although mouse models have clearly shown the potent antitumor effects of CpG, clinical results have so far been disappointing, with recent phase 2 and 3 trials in non-small cell lung cancer being dropped due to the failure of s.c. CpG-ODN administration to improve clinical outcome [28].

In tumor xenograft mouse models, erlotinib clearly reduced the growth of tumors with high levels of EGFR expression.

The mouse models also clearly suggest that inappropriate p53 activity promotes aging while a robust but normally regulated p53 response protects from the aging process.