Sentence examples for mouse models indicates from inspiring English sources

However, the high degree of growth retardation and peri-natal mortality in IGF-I deficient mouse models indicates that it plays a critical role during this time.

A wealth of evidence obtained using mouse models indicates that CD4+CD25+FOXP3+ regulatory T cells (Treg) maintain peripheral tolerance to self-antigens and also inhibit anti-tumor immune responses.

Finally, evidence from mouse models indicates that genetic disorders affecting the architecture of subchondral bone can cause OA.

Furthermore, evidence from mouse models indicates that the mammary repopulating units with functional stem cell activity are not contained within the SP [ 9, 18].

Although the physiological functions of APP and APLPs are not fully understood, evidence from mouse models indicates a key role of the APP family for neuronal migration, synaptogenesis, synaptic function and plasticity [ 6- 8].

This variation in phenotype between the different mouse models indicates that either PDK1 has PI-3 kinase/Akt-independent roles, or that the PI3Kα/PI3Kδ pro-B cells still had a low level of Akt activity.

Short telomeres, a hallmark of dyskeratosis congenita, impair tissue stem cell function in mouse models, indicating that a tissue stem cell defect may underlie the pathophysiology of dyskeratosis congenita.

Results from SMA mouse models indicate ISIS-SMNRx had a significant effect on functional and histological measures of neuromuscular health when delivered to the CNS.

However, recent findings in preclinical mouse models indicate that infusion of T-cells directed against tumor-associated auto-antigens can be associated with higher 'on target' toxicity than was anticipated on the basis of anti-tumor vaccination studies.

Previous work revealed that functional deficiency in microglia is associated with much more severe deposition of amyloid plaques in AD mouse models, indicating a protective role of microglia in AD (Zhang et al., 2007).

Together, our observations in these two mouse models indicate that a B cell response is required for the development of granulomas early in Schistosoma infection.