Sentence examples for mouse mammary development from inspiring English sources

Mouse mammary development proceeds through multiple morphologically well-defined steps.

The EMT process has been described in detail in both mouse mammary development and tumorigenesis (see reviews in [ 33]).

EGFR, ErbB2, and ErbB3 are required for normal mouse mammary development at puberty, but ErbB4 has mainly been implicated in pregnancy and in lactation [ 4, 28- 32].

From studies of mouse mammary development and human mammary epithelial cells grown in three-dimensional culture, acini structures have been recapitulated and manipulated in order to elucidate organization and development [ 5, 7, 8].

The principal objective of the present study was to provide a comprehensive set of gene expression data from late stages of mouse mammary development to be used as an online resource for further analysis and/or download.

Moreover, they provide additional insights into the use of specific cytokeratins as markers of mammary epithelial differentiation, or the use of their promoters to direct gene overexpression or ablation in genetic studies of mouse mammary development.

In mice, mammary development begins shortly after mid-gestation, when bilateral epidermal ridges (or milk lines) form from forelimb to hindlimb, along which five pairs of disk-shaped placodes form at the site of each future nipple (this stage of mammary development is reviewed in the initial article in this series [ 5]).

In most aspects, human breast development resembles mouse mammary gland development [ 17], although there are some notable differences [ 18].

TGF-β exposure markedly suppresses mouse mammary tumor development [ 32] and reversibly inhibits normal mammary gland growth [ 33].

Here we show that canonical Wnt signals through the Lrp6 co-receptor are also required for normal mouse mammary gland development.

Wnt5A is known to be expressed and bioactive during mouse mammary gland development; a gain of function inhibits ductal outgrowth, and loss promotes hyperproliferation [52].