Sentence examples for mouse knockout strains from inspiring English sources

Further characterization of these two mouse knockout strains, showed that Cox-2 was critical for postnatal kidney development and function [32].

To facilitate more meaningful comparisons with other mouse knockout strains, we backcrossed these mice nine times to a C57BL/6 background and generated B6 VC- (n = 15) and B6 VC+ (n = 15) mice in a C57BL/6 background.

This approach revealed that 7 lincRNAs from our mouse knockout strains have human orthologs that are dynamically induced during in vitro human neuronal differentiation.

IL-17RAKO mice showed a similar pattern of arthritis as IL-23p19KO mice did, and this was significantly suppressed in both mouse knockout strains compared to WT mice.

Through internationally coordinated efforts, the International Knockout Mouse Consortium (IKMC) has generated a public resource of mouse knockout strains and, in April 2012, the International Mouse Phenotyping Consortium (IMPC), supported by the EU InfraCoMP programme, convened a workshop to discuss developing a phenotyping pipeline for the investigation of embryonic lethal knockout lines.

The mouse knockout strain only displays a mild increase in ubiquitylation levels in brain and testis [20].

Unexpectedly, we found no differences in C. albicans colonization in either mouse knockout strain.

A mouse knockout strain with a complete disruption of the Ugt1 gene cluster by the insertion of the Neo cassette has recently been reported (8) showing, similarly to our results, that homozygous mutant mice die within 2 wk after birth.

To determine whether the deficiency of defined molecular components of PNs had a constitutive effect on the number of PNs, we assessed the numerical density of neurons with and without PN in the barrel field cortex of each different mouse knockout strain.

To this end, protection of PN-ensheathed neurons was differentially analysed after microinjection of FeCl3 into the barrel field cortex, in four different mice knockout strains, each being deficient for a different component of PNs, such as aggrecan (ACAN+/−), lacking brevican (BCAN−/−), link protein (HAPLN1−/−) or tenascin-R (TN-R−/−) knockout mice.

To identify molecular components that essentially mediate the neuroprotective aspect on PN-ensheathed neurons, we comparatively analysed neuronal degeneration induced by a single injection of FeCl3 on four different mice knockout strains, each being deficient for a different component of PNs.