Sentence examples for mouse knockout models from inspiring English sources

In recent years, several types of mouse knockout models have been developed that have provided useful tools for experimental investigation of NRP1 function, and a multitude of therapeutics targeting NRP1 have been designed, mostly with the view to explore them for cancer treatment.

Despite the very high degree of similarity between p63 and p73, mouse knockout models reveal distinct and non-redundant physiological roles.

Mouse knockout models have shown that heat shock transcription factor-1 (HSF1) is the key regulator of the HSR [1] [3].

However, delays have been encountered in generating mouse knockout models, and therefore there remain gaps in the information that urgently need bridging.

Mouse knockout models demonstrate that deficiencies of either podocyte-specific genes, encoding for podocin [37], nephrin [38], and Neph1 [39] or more ubiquitously expressed genes, encoding for α-Actn4 [33], CD2AP [40] and Fyn [41] can result in podocyte dysfunction leading to progressive glomerular disease.

Mouse knockout models of the PRLR have confirmed the importance of the PRL in reproduction (reviewed by [ 23]).

We also performed Creb1 immunohistochemistry on sections of Creb1−/− lungs to validate our mouse knockout model.

We observed that complex II-dependent respiratory capacity is upregulated in matrix arm, subcomplex 1λ subunit dysfunction, as is consistent with a mouse knockout model of the subcomplex 1λ NDUFsubunitnit [15].

10.7554/eLife.06358.005 Figure 2. Progressive RGS7 loss in the ON-BC neurons of a conditional mouse knockout model (cDKO).

Subsequent work using a mouse knockout model supported the role of ME1 in determining susceptibility to T2D.

Furthermore, a mouse knockout model demonstrated 90% mortality and decreased clearance of L. pneumophila infected, TNF receptor deficient mice, in comparison with wild-type mice (10 ).