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Studies in mouse have identified Nr5a1 as a key gene involved in gonadal sex determination, differentiation, and maintenance.
Studies of the cellular origin of NSCLC in the mouse have identified a number of candidates [55], [56], but their relationship to Kras4A remains to be determined.
Detailed analyses of ICC progenitors in the mouse have identified KITlowCD34+INSR+IGF1R+ stem cells, KIThighCD34+INSR+IGF1R+ committed progenitors, and mature ICCs with a KIThighCD34−INSR−IGF1R− phenotype [ 31, 32].
Previous studies in mouse have identified a 2.2 kb fragment containing 3 GBS upstream of the olig2 promoter that can recapitulate the endogenous expression pattern in the neural tube (Wang et al., 2011).
Extensive genetic and biochemical analyses of the PCD including this species and other genetic model systems such as fruit fly and mouse have identified more components that are responsible for the survival or death of cells (Fraser et al., 1999; Hay et al., 2004; Kornbluth and White, 2005; Steller, 2008; Fuchs and Steller, 2011).
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Genetic analysis of the NOD mouse has identified around 50 disease loci, which have the nomenclature Idd for insulin-dependent diabetes, distributed across at least 11 different chromosomes.
Our ongoing characterization of the Id2−/− mouse has identified characteristics shared with PD patients and several different animal models of PD (Dauer and Przedborski, 2003).
Genetic engineering studies in mice have identified a number of subunits that are critical for the ability of nicotine to activate the reward system in the brain, consisting of the dopaminergic cell bodies in the ventral tegmental area and their terminals in the nucleus accumbens and other portions of the mesolimbic system.
Studies of homozygous shiverer mutant mice have identified ATF2 as a regulator of the expression of MAG expression at a specific stage of shi/she oligodendrocyte differentiation [270].
Detailed immunohistochemical studies in mice have identified highly regulated, specific domains of discrete and dynamic ERK phosphorylation throughout development, including the pharyngeal arches and limb buds [26].
Multiple studies of adiposity and hypertension in genetic crosses from rats and mice have identified a large number of QTL associated with these traits [13] [18].
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