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While important, these studies have targeted suppression of the human disease transgene in the mouse and therefore have not investigated the effects of concomitant wild-type allele suppression or investigated the mechanistic basis for specific suppression of polyQ disease alleles.
The collection technique is non-invasive to the mouse and therefore repeatable.
Neostigmine is an acetylcholinesterase inhibitor that ameliorates the effects of APAP-induced acute liver failure in the mouse and therefore may provide new treatment options for affected patients.
All the examples listed in [ 62] are not present in mouse and therefore are expected to have been exapted in the last 100 Myrs.
The model appears to model the human disease phenotype more faithfully than the previously reported Ndrg1 knockout mouse and therefore represents an additional tool for research.
Of the development-related genes defined in our study we identified 18% by orthology that also had been shown to bind STAT5 in the mouse and therefore are potentially growth hormone responsive.
Similar(51)
This study, however, was performed in a xenograft model in SCID mice, and therefore, the metabolic stability of both radiotracers was determined again in SCID mice and results were compared with previously obtained rat data [19, 20].
As SCN1A is highly expressed within the SA node in mice and therefore might play an important role in normal rhythmogenesis [11], a higher amount of SCN1A gene product at earlier developmental stages has been suggested to be responsible for the physiologically higher heart rate at younger age [13].
Activity suppression normalizes for general activity levels of the mice and therefore corrects for potential hypo- and hyper-activity [26].
Similarly, the presence of pinyon mice (a larger-bodied competitor) may decrease encounters between deer mice, and therefore reduce opportunities for SNV transmission.
Cell death was slightly higher in wildtype-βTag mice and therefore does not appear to contribute to the smaller size of tumors in Perk KO-βTag mice.
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