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Chan et al. (2006) also showed that brain areas such as bilateral sensorimotor, supplementary motor area, left parietal, and right cerebellum were activated during the fist-edge-palm task [ 7].

Compared with control subjects, adolescents with IGD showed significantly higher global cerebral blood flow in the left inferior temporal lobe/fusiform gyrus, left parahippocampal gyrus/amygdala, right medial frontal lobe/ACC, left insula, right insula, right middle temporal gyrus, right precentral gyrus, left supplementary motor area, left cingulate gyrus, and right inferior parietal lobe.

We found that the IGA group showed increased CBF in the left inferior temporal lobe, left parahippocampal gyrus and amygdala, right medial frontal lobe/anterior cingulate cortex, bilateral insula, right middle temporal gyrus, right precentral gyrus, left supplementary motor area, left cingulate gyrus, and right inferior parietal lobe compared with the control group.

Compared with control subjects, adolescents with IGA showed significantly higher global CBF in the left inferior temporal lobe/fusiform gyrus, left parahippocampal gyrus/amygdala, right medial frontal lobe/anterior cingulate cortex, left insula, right insula, right middle temporal gyrus, right precentral gyrus, left supplementary motor area, left cingulate gyrus, and right inferior parietal lobe.

Compared with the control group, the IGA group showed increased CBF in the left inferior temporal lobe, left parahippocampal gyrus/amygdala, right medial frontal lobe/anterior cingulate cortex, bilateral insula, right middle temporal gyrus, right precentral gyrus, left supplementary motor area, left cingulate gyrus, and right inferior parietal lobe.

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Greater pain relief was associated with decreased BOLD activity in the right superior frontal gyrus (Figure 1c), left dorsal anterior cingulate cortex (Figure 1c), right brainstem (located in the substantia nigra and red nucleus region; Figure 1d), left anterior insula, right putamen, left supplementary motor area, and left parahippocampal area.

Specific regions that showed increased functional connectivity during the sad recall condition (B* - B) included the dorsal anterior cingulate and supplementary motor area, and left anterior insula and opercular region.

In addition to putamen responses, our whole-brain analysis showed that the supplementary motor area and left premotor cortex were more active for beat than nonbeat rhythms.

Activation responses to GD in ventral parietal cortex and posterior insula as well as somatosensory and motor areas were left lateralized.

They also found a negative correlation of TUG number of steps with subcortical white matter in the left supplementary motor area (SMA) and left anterior limb of the internal capsule.

Individual variation in the modified Moral Judgment Interview (mMJI) scores correlated positively with BOLD responses in the supplementary motor area (SMA) and left STS (Figure 2) for the justice>neutral contrast; BOLD responses in the right dACC were negatively correlated with individual mMJI scores (Table S1).

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