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Variants lacking either the SD phosphorylation sites or the SBD SH3-binding motif were able to partially restore the migration response, while only a variant lacking both signaling functions was fully defective.
Although in our study, the selected peptide was unable to bind to the stem cell line of the other species, further proves its specificity, we still observed that several peptides with "homologous core sequence", namely the PWX (L/V) motif, were able to bind to differentiated ES cells, albeit with low efficiency.
Appelbaum et al. showed that folded miniature proteins containing a discrete pentaarginine motif were able to effectively overcome endosomal entrapment and reach the cytosol of mammalian cells.
All four of the randomly chosen genomic regions containing the motif were able to bind Bapx1 in vitro (Additional file 7: Figure S2A).
In another example, truncated forms of the Drosophila transcription factor Fos, encoding a leucine zipper motif, were able to inhibit wild-type Fos activity (Pierre et al. 2008).
Similar(55)
While elafin is formed by a single WAP motif and interacted weakly with PLSCR1, SLPI contains two WAP motifs and each motif was able to support binding to PLSCR1, indicating that both domains may cooperate in an additive manner leading to an optimal interaction with PLSCR1.
An interpretation of these results is that the change in the YxCxxxF motif is able to discriminate between the UAG and UAA codon.
The latter motif was able to functionally mediate RRIG1 antitumor activity by suppressing tumor cell viability and cyclin D1 expression [ 7].
These results conclusively demonstrate that the ALPS motif is able to bind GA membranes in the absence of any other targeting signal.
This suggests that the triazole motif is able to mimic the interaction of the pyrophosphate with the binding site to some extent.
These studies demonstrated that the c-kit quadruplex motif was able to fold into non-duplex states within a natural extended DNA duplex.
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