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The motif is embedded in a large array of interactions that stabilize the monomer and the dimer.

The motif is embedded within these binding sites.

In natural systems, however, this motif is embedded inside a large regulatory network with many other interactions.

Importantly, the HMG motif is embedded in a 50 aa sequence stretch that shows only little homology between the different species (data not shown).

The autocatalytic cleavage activity of the GPS in different molecular contexts has been investigated in detail (Lin et al., 2004; Wei et al., 2007), and crystal structures revealed that the GPS motif is embedded within a larger GAIN (GPCR-autoproteolysis inducing) domain required and sufficient for GPS proteolysis (Araç et al., 2012).

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Analysis of the secondary-structure context in which these motifs are embedded might provide additional biological information that could increase the specificity/sensitivity of motif detection.

Because these motifs are embedded in the very AT-rich intergenic sequence characteristic of Tetrahymena and the functions of these motifs have not been experimentally confirmed for any gene in this organism, and thus remain hypothetical, we will not discuss them further.

However, in real systems motifs are embedded in large networks allowing for the combination of motifs.

It is conceivable that similar RNA motifs are embedded in larger, conserved structured regions that can be detected by RNAz.

To help researchers evaluate motif discovery programs objectively, benchmark data sets have been created, in which known motifs are embedded into diverse sequences [ 16].

We show that in type VI secretion, contraction leads to exposure of the ClpV recognition motif, which is embedded in the type VI-specific four-helix-bundle N-domain of VipB.

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