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Exact(5)
The hinge between HC and Hn is mostly unstructured in the dichain form of BoNT/A [18].
The peculiar sequence properties of Henipavirus PNT and NTAIL suggest that these protein domains are mostly unstructured in solution.
In contrast, Pup is mostly unstructured in its free, unbound form [ 29- 31].
However, the BH3 domain peptides of proapoptotic proteins are mostly unstructured in aqueous solution, whereas they adopt a well-defined helical conformation in experimentally determined complex structures.
FlgM is a 97-residue polypeptide from Salmonella typhimurium, which regulates flagellar synthesis by binding to the transcription factor Δ. Free FlgM is mostly unstructured in dilute solution, but its C-terminal half can form a transient α-helix.
Similar(54)
Also, affinity enhancement from tyrosine or lysine substitution in several positions of the peptide is consistent with the idea that, in mostly unstructured peptides, modest affinity can be achieved from a few interacting residues separated by relatively flexible non-interacting residues.
The C-terminal 300 residues (Art-Cter), which follow the core metallo-β-lactamase and β-CASP domains, are predicted to be mostly unstructured and seem to have a function in regulating Artemis endonuclease activities [73,77,78].
These results suggest that within the subensemble of mostly unstructured states, the energy landscapes are dominated by states in which parts of helices adopt structure, whereas structure formation for sequences destined for β-strand is far less probable.
The CD spectrum of GIG47 shown in Figure 4A indicates that it is mostly unstructured.
Such short signals would "drown" in the noise of longer alignments that are then mostly unstructured.
Prior to zygotic genome activation, the genome is mostly unstructured.
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