Sentence examples for largely unstructured in from inspiring English sources
Repeats two, six, and seven remain largely unstructured in this intermediate, becoming structured in a second kinetic step that leads to the native state.
Consequently, the PK-labile amino-terminus has been suggested to be solvent-accessible and largely unstructured in the context of PrPSc as it is in PrPC [3], [4].
Many studies suggest that P6 remains largely unstructured in the mature virion, and interacts with VPR.
As the β3 β4 loop is largely unstructured in the isolated F0 domain, this contact is likely to have only a minor effect on the inter-domain orientation.
The positively charged histone tails, which make minimal intranucleosomal interactions within crystal structures, are thought to be largely unstructured in solution and are highly dynamic.
In summary, long molecular dynamics and replica exchange Monte Carlo simulations suggest that the AChE peptide remains helical in the tetramerization complex and when part of a longer helical peptide but is largely unstructured in solution under normal physiological conditions.
Amazingly, there is a long region over residues Gly33-His86 without significant changes of chemical shifts upon partitioning into the DPC micelle, indicating that even in the membrane environment this region remains largely unstructured as in aqueous solution.
Taken together, the above results show that enforcing covalent dimerization via an interchain disulfide bond at position 54 and/or position 107 stabilizes a conformation of NEMO that is largely α-helical in the IKKβ binding region extending roughly from residues 50 108, but that the protein outside of this region remains largely unstructured especially in the longer, NEMO1 120 constructs.
In line with this finding, I observed a largely unstructured innovation process in the development of ATMs.
Aβ is a largely unstructured peptide fragment in aqueous solution, while TTR is a tetramer composed of immunoglobulin-like β-sandwich domains.
Although specific structured or shared care programmes for diabetes have been developed in some areas [ 2, 6], recent research suggests that the delivery of diabetes care in primary care remains largely unstructured [ 7] and in many areas the delivery of diabetes care remains very hospital-based.
