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First, cerebellar signs appeared mostly in advanced age and mainly consisted in ataxia and dysmetria with intention tremor, whereas nystagmus was never described [3, 7].

Although p.Arg583Gln mutations are associated with a heterogeneous phenotype, carriers present cerebellar signs which consisted generally in ataxia and dysmetria, with intention tremor appearing mostly in advanced age, often progressive and permanent.

Although about 80% of patients with pancreatic cancer are positive for serum CA19-9, mostly in advanced stages, false-positive rates are very high (20 30%) in patients with beginning hepatobiliary-pancreatic diseases [5].

However, the renal biopsy remains a crucial diagnostic point through the demonstration of a hypocellular interstitial fibrosis with a decreasing corticomedullary gradient, mostly in advanced cases of kidney disease.

The patients were mostly in advanced stages, distributed as follows: 6 cases corresponded to stage I, 64 to stage II and 39 to stage III.

Our findings on mortality are worse than they reported because the populations studied were mostly in advanced stages of the disease.

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Ovarian carcinoma is mostly diagnosed in advanced stages when intraperitoneal metastasis has already taken place.

Most of the candidate markers have been evaluated in clinical settings and are mostly detected in advanced stages.

As no effective screening is available, it is mostly diagnosed in advanced and metastatic stages [ 2] and therefore it is associated with a poor overall prognosis.

Lussier and Choiniere showed that decline in mortality related to cardiovascular disease was mostly concentrated in advanced ages, and the decline did not occur at the same pace for men and women (47).

The governmental hospitals report cervical cancer to be up to 28% among all female cancer cases, representing 75% of all gynaecological cancers that are mostly diagnosed in advanced stages (Tjindarbumi and Mangunkusumo, 2002; Aziz, 2009).

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