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This defined p22 as the most variable protein in human noroviruses [39].
A closer look at the phylogenetic tree based on the most variable protein, cell attachment protein sigma C (Figure 6), indicated that the Malaysian bat isolate (PulV) is more closely related to the three human isolates (MelV, KamV and HK) than to the Australian bat isolate (NBV).
As the viral major outer capsid protein, VP7 is the most variable protein in aquareoviruses.
RSV's most variable protein, the attachment (G) glycoprotein, is also a target of protective antibody responses, and analysis of its encoding genome portion shows continuous accumulation of genetic changes leading to antigenic drift (3, 4 ).
The envelope protein, GP5, is the most variable protein of the PRRSVs, with only 51%to55%5% sequence identity shared between the Type-1 and Type-2 strains [ 28, 35].
Similar(54)
The COI gene encompasses the 'Folmer region' used in DNA barcoding, and the cytB gene, located nearly opposite COI on the circular mitochondrial genome [ 28], is among the most variable protein-encoding genes in insects (R. Meier, unpublished data).
The 50 most variable proteins mirrored the dominant functional groupings of the high dN/dS analysis (Additional file 7: Table S6), including esxE/F as well as enoyl-CoA hydratase echA4_2 and ssp.
Most of the detected mutations are present in the HA segment, which is also the most variable influenza protein in nature [ 70].
Phylogenetic trees derived from nucleotide sequences of the complete genome or the most variable envelope protein gene of selected JEV strains (Table 1) indicated that both JEV isolates from bats are members of genotype III as defined by Solomon et al. (3 ).
The NS3, NS4A/B, and NS5 proteins were the most variable viral proteins.
The GP3 protein is one of the most variable structural proteins among the PRRSVs, with only 54% to 60% AA sequence identity shared between the Type-1 and Type-2 strains [ 24, 35].
Related(20)
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