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In ad 1089 one of the most severe epidemics was known as St. Anthony's fire because those who prayed to St. Anthony were said to recover; others, who did not, died.
A closer look at the outbreak patterns revealed that the most severe epidemics seemed to happen in a 3-year cycle.
Brazil has the highest number of dengue cases in the world, with the most severe epidemics in the city of Rio de Janeiro Rioo).
After 3 years of a widespread programme, no severe reactions occurred, and one of the most severe epidemics was practically eradicated.
South Africa is facing one of the most severe epidemics of HIV in the world (Department of Health, 1999), and miners have certainly not escaped infection.
HFRS in China has the most severe epidemics having about 90% of the total reported HFRS cases in the world [ 1- 4].
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In the UK, the Department of Health wrote, before swine flu emerged, that "we can assume [that the next pandemic] will be of greater magnitude than even the most severe epidemic of 'ordinary' flu".
The most severe epidemic occurred from 1980 to 1990 and resulted in 55,367 human deaths (2 ).
It was the longest and most severe epidemic in 3 decades; 5,737 persons were affected in 7 districts of eastern Uttar Pradesh, and 1,344 persons died (1 ).
We describe laboratory and clinical findings from 1,559 patients, including 62 who died during the largest and most severe epidemic that has occurred in Rio de Janeiro since DENV became endemic in the country in 1986.
Indeed, 1 year after the DENV-3 introduction, this serotype was responsible for the most severe epidemic in the state's history in terms of the highest number of reported cases, the severity of clinical manifestations, and the number of confirmed deaths.
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