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"most severe cases" is correct and usable in written English.
You can use it to describe any situation where a particular intensity or degree is being discussed. For example, "The hospital has seen some of the most severe cases of chickenpox this year."
Exact(60)
Probably one of the most severe cases in the country.
In the most severe cases, it has required joint replacements.
In the most severe cases, legs are amputated.
There is no vaccine to protect against it and, in the most severe cases, no cure.
But it would be reserved for the most severe cases if VIG failed.
But only the most severe cases would be admitted and allowed to stay overnight.
Every three hours, the most severe cases are drip-fed the nutritious milk product, F-75.
When outbreaks like the current one occur, only the most severe cases tend to be found.
Further complications of cardiopulmonary failure lead to death in the most severe cases.
At the moment, due to the prohibitive cost only the most severe cases are treated in many poorer countries.
In the most severe cases it can lead to liver failure or liver cancer, both of which can be fatal.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com