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In the 18 patients with primary tumors (gliomas and meningiomas), thalamic as well as temporal and parietal cortical K values showed significant positive correlations with BDI-II depression scores (Additional file 1: Table S2); the most robust correlation was again found with thalamic K values (r = 0.68; p = 0.004), similar to the whole-group results.
The most robust correlation with metastasis regarded primarily the protein S100A4, and secondly the protein S100A7.
Interestingly, the most robust correlation with NOx depletion was %iAs in blood (p < 0.001).
Overall, the relative delta percentage appears to provide the most robust correlation with CBF and metabolism during focal ischemia.
To this end, we identified nine biomarkers that had the most robust correlation with dysplasia in BO based on published phase III and IV clinical studies.
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In the whole group, the BDI-II depression scores showed a significant positive correlation with thalamic and temporal cortical K values, with the most robust correlations found for the thalamic values (r = 0.63; p = 0.004), that remained significant even after Bonferroni correction for multiple correlations (Additional file 1: Table S1, Fig. 2).
The most robust correlations in the favorite-food cue and stress conditions were seen with HOMA-IR.
At baseline, the most robust correlations (significant relationships with insulin sensitivity were found in all subjects and in both NAFL groups analyzed separately) were present among the lyso-PCs (Supplementary Table 4).
Low-frequency temporal correlations were observed between gray matter horns in all subjects, and examples of these correlations are presented in Figure 3 and Figure 4. Within a given axial slice, the strongest and most robust correlations were between left and right ventral horns.
DOI: http://dx.doi.org/10.7554/eLife.02812.006 A group-level analysis of functional connectivity between sub-regions of spinal cord gray matter and adjacent white matter confirmed that the most robust correlations are observed between left and right ventral (motor) horns (p < 0.01; corrected), as well as between left and right dorsal (sensory) horns (p < 0.01; corrected).
Therefore, we expect that the most robust multipollutant correlations were those based on all of the data combined.
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